RGD Reference Report - Variations in DNA topoisomerase I activity after gamma irradiation of mature neurons. - Rat Genome Database

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Variations in DNA topoisomerase I activity after gamma irradiation of mature neurons.

Authors: Ivanov, VA 
Citation: Ivanov VA Neurosci Lett. 1988 Nov 22;94(1-2):99-103.
RGD ID: 2317066
Pubmed: PMID:2853856   (View Abstract at PubMed)

The activity of DNA topoisomerase I in nuclear extracts from rat cerebral cortex neurons increases about two-fold after gamma irradiation (700 rads) of rats or incubated cerebral cortex slices. Analysis of the salt dependence of the DNA topoisomerase I association with chromatin shows a change of the activity only for tight-bound pool of the enzyme. The change appears to reflect a modification of the enzyme which results from its repair function.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Top1Ratresponse to gamma radiation  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Top1  (DNA topoisomerase I)


Additional Information