RGD Reference Report - Shear stress regulation of Kruppel-like factor 2 expression is flow pattern-specific. - Rat Genome Database

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Shear stress regulation of Kruppel-like factor 2 expression is flow pattern-specific.

Authors: Wang, N  Miao, H  Li, YS  Zhang, P  Haga, JH  Hu, Y  Young, A  Yuan, S  Nguyen, P  Wu, CC  Chien, S 
Citation: Wang N, etal., Biochem Biophys Res Commun. 2006 Mar 24;341(4):1244-51. Epub 2006 Jan 30.
RGD ID: 2316544
Pubmed: PMID:16466697   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2006.01.089   (Journal Full-text)

Flow patterns in blood vessels contribute to focal distribution of atherosclerosis; the underlying mechanotransduction pathways remain to be investigated. We demonstrate that different flow patterns elicit distinct responses of Kruppel-like factor-2 (KLF2) in endothelial cells (ECs) in vitro and in vivo. While pulsatile flow with a significant forward direction induced sustained expression of KLF2 in cultured ECs, oscillatory flow with little forward direction caused prolonged suppression after a transient induction. The suppressive effect of oscillatory flow was Src-dependent. Immunohistochemical studies on ECs at arterial branch points revealed that KLF2 protein levels were related to local hemodynamics. Such flow-associated expression patterns were also demonstrated in a rat aortic restenosis model. Inhibition of KLF2 with siRNA sensitized ECs to oxidized LDL-induced apoptosis, indicating a protective role of KLF2. In conclusion, differential regulation of KLF2 may mediate the distinct vascular effects induced by various patterns of shear stress.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to laminar fluid shear stress  IEP 2316544 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Klf2  (KLF transcription factor 2)


Additional Information