RGD Reference Report - Change in annexin A3 expression by regulatory factors of hepatocyte growth in primary cultured rat hepatocytes. - Rat Genome Database

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Change in annexin A3 expression by regulatory factors of hepatocyte growth in primary cultured rat hepatocytes.

Authors: Harashima, M  Niimi, S  Koyanagi, H  Hyuga, M  Noma, S  Seki, T  Ariga, T  Kawanishi, T  Hayakawa, T 
Citation: Harashima M, etal., Biol Pharm Bull. 2006 Jul;29(7):1339-43.
RGD ID: 2316071
Pubmed: PMID:16819165   (View Abstract at PubMed)

We have recently reported that annexin (Anx) A3 expression is necessary for hepatocyte growth in cultured rat hepatocytes seeded at half the subconfluent density on collagen. In the present study, we investigated the effects of various regulatory factors of hepatocyte growth on AnxA3 expression. AnxA3 expression was significantly reduced in hepatocytes cultured under various growth inhibitory conditions such as presence of dexamethasone, culture at subconfluent cell density, and on EHS-Matrigel and lactose-carrying styrene polymer. On the other hand, hepatocyte growth factor and epidermal growth factor, stimulators of hepatocyte growth, significantly increased AnxA3 expression in hepatocytes cultured on EHS-Matrigel. These results show close correlation between known stimulatory or inhibitory actions of various factors to hepatocyte growth and increase or decrease in AnxA3 expression, and suggest the involvement of AnxA3 in their regulation of hepatocyte growth.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to glucocorticoid  IEP 2316071 RGD 
response to growth factor  IEP 2316071 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Anxa3  (annexin A3)


Additional Information