RGD Reference Report - Relationship between cyclin G1 and human papilloma virus infection in cervical intraepithelial neoplasia and cervical carcinoma. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Relationship between cyclin G1 and human papilloma virus infection in cervical intraepithelial neoplasia and cervical carcinoma.

Authors: Liang, J  Bian, ML  Chen, QY  Liu, X  Ou, H  Li, M  Liu, J 
Citation: Liang J, etal., Chin Med Sci J. 2006 Jun;21(2):81-5.
RGD ID: 2316022
Pubmed: PMID:16845792   (View Abstract at PubMed)

OBJECTIVE: To evaluate the overexpression of cyclin G1 in cervical intraepithelial neoplasia (CIN) and cervical carcinoma, and the correlation between cyclin G1 and high-risk human papilloma virus (HPV) infection. METHODS: All of the specimens were obtained from the Department of Pathology of China-Japan Friendship Hospital from January 2000 to August 2004. We detected the expression of cyclin G1 with immunohistochemistry, HPV16/18 infection with in situ hybridization, and high-risk HPV infection with Hybrid capture system II (HC-II) in normal group (25 cases), CIN I (48 cases), CIN II (56 cases), CIN III (54 cases), and invasive cervical squamous-cell carcinoma (SCC, 31 cases). RESULTS: The positive rates of cyclin G1 expression in CIN (77.85%) and SCC cervical tissues (87.10%) were significantly higher than normal (8.00%, P < 0.01), and the intensities of cyclin G1 expression in CIN (40.60%) and SCC cervical tissues (61.51%) were significantly higher than normal (2.72%, P < 0.05). The positive rates and intensities of cyclin G1 expression increased gradually with the grade of cervical lesions. High-risk HPV infection rates were higher in CIN and SCC than normal groups (P < 0.05). There was a positive correlation between cyclin G1 expression and high-risk HPV infection detected with HC-II (Kendall's tau-b = 0.316, 0.269, 0.352, and 0.474 in CIN I, CINII, CIN III, and SCC, respectively, P < 0.05). CONCLUSIONS: Cyclin G1 is overexpressed in CIN and SCC. Cyclin G1 may be a biomarker for detecting CIN and SCC. Cyclin G1 may play an important role in the oncogenesis of CIN and SCC by high-risk HPV infection.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cervix uteri carcinoma in situ  IEP 2316022protein:increased expression:uterine cervixRGD 
cervix uteri carcinoma in situ  ISOCCNG1 (Homo sapiens)2316022; 2316022protein:increased expression:uterine cervixRGD 
papillomavirus infectious disease disease_progressionIEP 2316022associated with cervix carcinoma and protein:increased expression:cervix (human)RGD 
papillomavirus infectious disease disease_progressionISOCCNG1 (Homo sapiens)2316022; 2316022associated with cervix carcinoma and protein:increased expression:cervix (human)RGD 
Uterine Cervical Neoplasms  IEP 2316022protein:increased expression:uterine cervixRGD 
Uterine Cervical Neoplasms  ISOCCNG1 (Homo sapiens)2316022; 2316022protein:increased expression:uterine cervixRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccng1  (cyclin G1)

Genes (Mus musculus)
Ccng1  (cyclin G1)

Genes (Homo sapiens)
CCNG1  (cyclin G1)


Additional Information