RGD Reference Report - Effect of S-adenosylhomocysteine on sulfhydryl xenobiotic transmethylases in rat liver. - Rat Genome Database

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Effect of S-adenosylhomocysteine on sulfhydryl xenobiotic transmethylases in rat liver.

Authors: Loo, G  Smith, JT 
Citation: Loo G and Smith JT, Biochem Biophys Res Commun. 1985 Apr 30;128(2):965-71.
RGD ID: 2315835
Pubmed: PMID:3994729   (View Abstract at PubMed)

Rat liver cytosolic thiopurine methyltransferase and microsomal thiol methyltransferase were each found to be subject to control by the absolute molar ratio of S-adenosylmethionine to S-adenosylhomocysteine using cell-free enzyme preparations. As this ratio was lowered, inhibition of both sulfhydryl xenobiotic transmethylases occurred. On the other hand, when the ratio was decreased in vivo by the administration of D,L-homocysteine thiolactone to animals, this alteration was accompanied by an inhibition of only thiopurine methyltransferase activity. Thiol methyltransferase activity was not significantly affected after drug treatment, which would suggest that there is a compartmentalization of S-adenosylhomocysteine in the intact hepatocyte.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to organic cyclic compound  IEP 2315835D and L-homocysteine thiolactoneRGD 

Objects Annotated

Genes (Rattus norvegicus)
Tpmt  (thiopurine S-methyltransferase)


Additional Information