RGD Reference Report - Modulation of noradrenaline release in the median preoptic area by GABAergic inputs from the organum vasculosum of the lamina terminalis in the rat. - Rat Genome Database

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Modulation of noradrenaline release in the median preoptic area by GABAergic inputs from the organum vasculosum of the lamina terminalis in the rat.

Authors: Ushigome, A  Nomura, M  Tanaka, J 
Citation: Ushigome A, etal., Neurochem Int. 2004 Feb;44(3):139-44.
RGD ID: 2315495
Pubmed: (View Article at PubMed) PMID:14568556

Previous observations have shown that gamma-aminobutyric acid (GABA) receptor mechanisms modulate the release of noradrenaline (NA) in the median peptic nucleus (MnPO). The present study was carried out to investigate whether neural inputs from the organum vasculosum of the lamina terminalis (OVLT) to the MnPO are involved in the GABAergic modulation of NA release in the MnPO area using in vivo microdialysis techniques. In urethane-anesthetized rats, electrical stimulation (5 and 10 microA, 10Hz) of the OVLT region, but not its surrounding region, significantly enhanced dialysate NA concentration in the MnPO area. The enhancement in the NA level caused by the OVLT region stimulation was significantly increased by perfusion with either bicuculline (10 microM), a GABA(A) receptor antagonist, or phaclofen (10 microM), a GABA(B) receptor antagonist, through a microdialysis probe. The amount of the antagonist-induced increase was much greater in the phaclofen-treated group than in the bicuculline-treated group. These results show that the OVLT region may exert both excitatory and inhibitory influences on the release of NA in the MnPO area, and imply that the inhibitory influence may be mediated through GABA(B) receptors rather than GABA(A) receptors.

Annotation

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Gabbr1  (gamma-aminobutyric acid type B receptor subunit 1)


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