RGD Reference Report - Marlin-1 is expressed in testis and associates to the cytoskeleton and GABAB receptors. - Rat Genome Database

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Marlin-1 is expressed in testis and associates to the cytoskeleton and GABAB receptors.

Authors: Vidal, RL  Ramirez, A  Castro, M  Concha, II  Couve, A 
Citation: Vidal RL, etal., J Cell Biochem. 2008 Feb 15;103(3):886-95.
RGD ID: 2315466
Pubmed: PMID:17668444   (View Abstract at PubMed)
DOI: DOI:10.1002/jcb.21456   (Journal Full-text)

Marlin-1 is a GABA(B) receptor and Jak tyrosine kinase-binding protein that also associates with RNA and microtubules. In humans and rodents, expression of Marlin-1 is predominantly restricted to the brain, but expression in lymphoid cells has also been reported. Here, we have studied the distribution of Marlin-1 in testis and spermatozoa. Our results indicate that Marlin-1 is highly expressed in testis. The protein is abundant in spermatogonia, spermatocytes, spermatozoa, and Sertoli cells. We also have studied the subcellular distribution in spermatozoa. Marlin-1 is present in the tail and to a lesser degree in the head of the sperm cell. Finally, we have explored two protein interactions. Our findings demonstrate that Marlin-1 associates with a microtubule fraction and with GABA(B) receptors in testis suggesting that the set of protein interactions of Marlin-1 are conserved in different tissues.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein binding  IPIJakmip1 (Rattus norvegicus)2315466 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gabbr1  (gamma-aminobutyric acid type B receptor subunit 1)


Additional Information