RGD Reference Report - Increased GABA B receptor subtype expression in the nucleus of the solitary tract of the spontaneously hypertensive rat. - Rat Genome Database

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Increased GABA B receptor subtype expression in the nucleus of the solitary tract of the spontaneously hypertensive rat.

Authors: Spary, EJ  Maqbool, A  Saha, S  Batten, TF 
Citation: Spary EJ, etal., J Mol Neurosci. 2008 Jun;35(2):211-24. Epub 2008 Mar 13.
RGD ID: 2315462
Pubmed: PMID:18338268   (View Abstract at PubMed)
DOI: DOI:10.1007/s12031-008-9055-9   (Journal Full-text)

Expression of GABA(B) receptor messenger RNA (mRNA) in the central nervous system was compared between the spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rat. Polymerase chain reaction (PCR) revealed all the isoforms except B1e in cortex, hypothalamus, and medulla oblongata. In the nucleus of the solitary tract (NTS) and ventrolateral medulla (VLM), the B1a-c and 1 g isoforms were present as well as B2. Real-time PCR detected significantly higher levels of B1a (p < 0.01) and B2 (p < 0.05) mRNA in the NTS of SHR compared to WKY. A significant increase in B1a expression (p < 0.05) was detected in VLM. Immunolabeling suggested presynaptic and postsynaptic expression of B1a, B1b, and B2 subtypes throughout the NTS, with significant differences in distribution patterns and labeling between subtypes and between SHR and WKY. These findings suggest that GABA(B) receptors expressed by neurones in NTS may be involved in cardiovascular regulation and that changes in GABA(B) mRNA expression levels may contribute to the hypertensive state in SHR.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  ISOGabbr1 (Rattus norvegicus)2315462; 2315462mRNA:increased expression:brainRGD 
hypertension  IEP 2315462mRNA:increased expression:brainRGD 

Objects Annotated

Genes (Rattus norvegicus)
Gabbr1  (gamma-aminobutyric acid type B receptor subunit 1)

Genes (Mus musculus)
Gabbr1  (gamma-aminobutyric acid type B receptor subunit 1)

Genes (Homo sapiens)
GABBR1  (gamma-aminobutyric acid type B receptor subunit 1)


Additional Information