RGD Reference Report - Human papillomavirus type 16 E6 variants and HLA class II alleles among Japanese women with cervical cancer. - Rat Genome Database

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Human papillomavirus type 16 E6 variants and HLA class II alleles among Japanese women with cervical cancer.

Authors: Matsumoto, K  Yasugi, T  Nakagawa, S  Okubo, M  Hirata, R  Maeda, H  Yoshikawa, H  Taketani, Y 
Citation: Matsumoto K, etal., Int J Cancer. 2003 Oct 10;106(6):919-22.
RGD ID: 2314694
Pubmed: (View Article at PubMed) PMID:12918070
DOI: Full-text: DOI:10.1002/ijc.11332

The enhanced oncogenicity of particular human papillomavirus type 16 (HPV16) E6 variants is population-dependent, implying the involvement of additional genetic cofactors. This study was designed to investigate the association between E6 variants and human leukocyte antigen (HLA) polymorphism within a Japanese population. Fifty-seven women with HPV16-positive cervical cancer were analyzed for E6 sequence variation and its relationship to HLA class II alleles. Compared with local controls (n = 138) and published controls (n = 916), DRB1*1501 and DQB1*0602 frequencies were significantly increased among patients with HPV16 E6 prototype (n = 11). Additionally, DRB1*1502 was positively associated with a particular E6 variant designated D25E (n = 25), although we could not find a significant association between HLA class II alleles and L83V variants (n = 16). Our observations suggest that a specific match between E6 variant proteins and HLA types may contribute to HPV16-related cervical carcinogenesis.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Eb1  (histocompatibility 2, class II antigen E beta)

Genes (Homo sapiens)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)


Additional Information