RGD Reference Report - HLA-DRB1*1602 allele is positively associated with HPV cervical infection in Bolivian Andean women. - Rat Genome Database

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HLA-DRB1*1602 allele is positively associated with HPV cervical infection in Bolivian Andean women.

Authors: Cervantes, J  Lema, C  Valentina Hurtado, L  Andrade, R  Hurtado Gomez, L  Torrico, L  Zegarra, L  Quiroga, G  Asturizaga, D  Dulon, A  Prada, R  Panoso, W  Yashiki, S  Fujiyoshi, T  Sonoda, S 
Citation: Cervantes J, etal., Hum Immunol. 2003 Sep;64(9):890-5.
RGD ID: 2314693
Pubmed: (View Article at PubMed) PMID:12941545

Incidence of cervical cancer is high among Bolivian Andean women. Human papillomavirus (HPV) infection is known as the major risk factor of cervical cancer. The host immune system plays an important role in the outcome of HPV infection and associated malignancies. In order to study the immunogenetic background of Bolivian Andean women with regard to HPV infection status, we compared HLA class I and class II allele frequencies between 37 HPV positive and 68 HPV negative Bolivian women. Demographic variables, including distribution of Andean ethnicities, were similar in both groups. Comparison of HLA class I allele frequencies between both groups indicated no significant difference. In contrast, HLA class II DRB1*1602 allele, an Amerindian allele, was significantly higher in the HPV positive women compared with HPV negative controls (chi(2) = 5.2, p < 0.05, odds ratio = 3.17; 95% confidence interval = 1.4-8.8). HPV types present in the HPV positive group were HPV-18, -16, -31, -33, and -58. These results suggest that HLA class II DRB1*1602 may confer susceptibility to infection with genetically related HPV types. This is the first report of an HLA class II association with HPV infection in an Andean population.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Eb1  (histocompatibility 2, class II antigen E beta)

Genes (Homo sapiens)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)


Additional Information