RGD Reference Report - Differential dyslipidemia associated with albuminuria in type 2 diabetic patients in Taiwan. - Rat Genome Database

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Differential dyslipidemia associated with albuminuria in type 2 diabetic patients in Taiwan.

Authors: Tseng, CH 
Citation: Tseng CH Clin Biochem. 2009 Jul;42(10-11):1019-24. Epub 2009 Mar 24.
RGD ID: 2313979
Pubmed: PMID:19324028   (View Abstract at PubMed)
DOI: DOI:10.1016/j.clinbiochem.2009.03.013   (Journal Full-text)

BACKGROUND: This study evaluated the lipid abnormalities associated with different stages of albuminuria in type 2 diabetic patients. METHODS AND RESULTS: A total of 549 patients (245 men and 304 women) with mean age of 63.4 were studied. Normoalbuminuria (n=251), microalbuminuria (n=242) and macroalbuminuria (n=56) were defined as albumin-to-creatinine ratio of < 30, 30-299 and > or = 300 microg/mg, respectively. Lipid parameters included total cholesterol, triglyceride (TG), high- and low-density lipoprotein (LDL) cholesterol, apolipoproteins A1 and B (ApoB), and lipoprotein(a) [Lp(a)]. Results showed that ApoB differed significantly (p<0.05) between normoalbuminuria and microalbuminuria/macroalbuminuria and Ln[Lp(a)] differed between normoalbuminuria/microalbuminuria and macroalbuminuria. Ln(TG) increased progressively with increasing albuminuria. In multivariate logistic regression analyses, only ApoB showed significant odds ratio (95% confidence interval) for microalbuminuria: 1.013 (1.004-1.022); and both ln(TG) and ln[Lp(a)] were significant for macroalbuminuria [respective odds ratios: 1.995 (1.010-3.938) and 1.708 (1.200-2.430)]. CONCLUSIONS: A differential dyslipidemia is observed for microalbuminuria and macroalbuminuria. Apo(B) and Lp(a) increase at the stages of microalbuminuria and macroalbuminuria, respectively. However, TG increases significantly throughout the three stages of albuminuria.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Diabetic Nephropathies  IEP 2313979associated with Diabetes Mellitus and Non-Insulin-DependentRGD 
Diabetic Nephropathies  ISOAPOB (Homo sapiens)2313979; 2313979associated with Diabetes Mellitus and Non-Insulin-DependentRGD 

Objects Annotated

Genes (Rattus norvegicus)
Apob  (apolipoprotein B)

Genes (Mus musculus)
Apob  (apolipoprotein B)

Genes (Homo sapiens)
APOB  (apolipoprotein B)


Additional Information