RGD Reference Report - Correlation of maternal serum fetuin/alpha2-HS-glycoprotein concentration with maternal insulin resistance and anthropometric parameters of neonates in normal pregnancy and gestational diabetes.

General

Correlation of maternal serum fetuin/alpha2-HS-glycoprotein concentration with maternal insulin resistance and anthropometric parameters of neonates in normal pregnancy and gestational diabetes.
Authors:	Kalabay, L Cseh, K Pajor, A Baranyi, E Csakany, GM Melczer, Z Speer, G Kovacs, M Siller, G Karadi, I Winkler, G
Citation:	Kalabay L, etal., Eur J Endocrinol. 2002 Aug;147(2):243-8.
RGD ID:	2313814
Pubmed:	PMID:12153747 (View Abstract at PubMed)
OBJECTIVE: Human fetuin/alpha(2)-HS-glycoprotein (AHSG) is a 49 kDa serum and tissue protein which is a natural inhibitor of insulin receptor signaling. We investigated serum AHSG levels during pregnancy and whether the protein is involved in insulin resistance observed in healthy pregnant women and patients with gestational diabetes. DESIGN: One hundred and four healthy pregnant women and 23 of their neonates, 30 patients with gestational diabetes and their neonates and 30 healthy age-matched non-pregnant females as a control group were investigated in a case-control cross-sectional study. METHODS: Serum AHSG was determined by radial immunodiffusion. RESULTS: We observed an increase of serum AHSG concentration in the second and third trimesters. Gestational diabetes patients had significantly higher AHSG levels than healthy pregnant women and non-pregnant controls. There was a highly significant positive correlation between serum AHSG concentration and indirect parameters of insulin resistance, i.e. tumor necrosis factor-alpha (TNF-alpha), leptin, C-peptide and C-peptide/blood glucose ratio. There was also a negative correlation between maternal AHSG, TNF-alpha, leptin levels and head circumference, body length and body weight of newborns. CONCLUSION: AHSG, TNF-alpha and leptin may contribute to insulin resistance during normal pregnancy and gestational diabetes. AHSG along with these cytokines may also negatively regulate neonatal skeletal development.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
gestational diabetes		IEP		2313814	protein:increased expression:serum	RGD
gestational diabetes		ISO	AHSG (Homo sapiens)	2313814; 2313814	protein:increased expression:serum	RGD

Objects Annotated

Genes (Rattus norvegicus)

Ahsg (alpha-2-HS-glycoprotein)

Genes (Mus musculus)

Ahsg (alpha-2-HS-glycoprotein)

Genes (Homo sapiens)

AHSG (alpha 2-HS glycoprotein)

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Correlation of maternal serum fetuin/alpha2-HS-glycoprotein concentration with maternal insulin resistance and anthropometric parameters of neonates in normal pregnancy and gestational diabetes.