RGD Reference Report - Upstream transcription factor 1 (USF1) in risk of type 2 diabetes: association study in 2000 Dutch Caucasians. - Rat Genome Database

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Upstream transcription factor 1 (USF1) in risk of type 2 diabetes: association study in 2000 Dutch Caucasians.

Authors: Meex, SJ  Van Vliet-Ostaptchouk, JV  Van der Kallen, CJ  Van Greevenbroek, MM  Schalkwijk, CG  Feskens, EJ  Blaak, EE  Wijmenga, C  Hofker, MH  Stehouwer, CD  De Bruin, TW 
Citation: Meex SJ, etal., Mol Genet Metab. 2008 Jul;94(3):352-5. Epub 2008 Apr 28.
RGD ID: 2313793
Pubmed: PMID:18445538   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ymgme.2008.03.011   (Journal Full-text)

Type 2 diabetes shares substantial genetic and phenotypic overlap with familial combined hyperlipidemia. Upstream stimulatory factor 1 (USF1), a well-established susceptibility gene for familial combined hyperlipidemia, is postulated to be such a shared genetic determinant. We evaluated two established variants in familial combined hyperlipidemia (rs2073658 and rs3737787) for association with type 2 diabetes in two Dutch case-control samples (N=2011). The first case-control sample comprised 501 subjects with type 2 diabetes from the Breda cohort and 920 healthy blood bank donors of Dutch Caucasian origin. The second case-control sample included 211 subjects with type 2 diabetes, and 379 normoglycemic controls. SNP rs2073658 and SNP rs3737787 were in perfect linkage disequilibrium. In the first case-control sample, prevalence of the major allele was higher in patients than in controls (75% versus 71%, OR=1.25, p=0.018). A similar effect-size and -direction was observed in the second case-control sample (76% versus 72%, OR=1.22, p=0.16). A combined analysis strengthened the evidence for association (OR=1.23, p=0.006). Notably, the increased risk for type 2 diabetes could be ascribed to the major allele, and its high frequency translated to a substantial population attributable risk of 14.5%. In conclusion, the major allele of rs2073658 in the USF1 gene is associated with a modestly increased risk to develop type 2 diabetes in Dutch Caucasians, with considerable impact at the population level.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 2 diabetes mellitus  IAGP 2313793DNA:SNP: :rs2073658 (human)RGD 
type 2 diabetes mellitus  ISOUSF1 (Homo sapiens)2313793; 2313793DNA:SNP: :rs2073658 (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Usf1  (upstream transcription factor 1)

Genes (Mus musculus)
Usf1  (upstream transcription factor 1)

Genes (Homo sapiens)
USF1  (upstream transcription factor 1)


Additional Information