Inverse association between serum resistin and insulin resistance in humans.

Authors: Dominguez Coello, S  Cabrera de Leon, A  Almeida Gonzalez, D  Gonzalez Hernandez, A  Rodriguez Perez, MC  Fernandez Ramos, N  Brito Diaz, B  Castro Fuentes, R  Aguirre Jaime, A 
Citation: Dominguez Coello S, etal., Diabetes Res Clin Pract. 2008 Nov;82(2):256-61. Epub 2008 Sep 11.
Pubmed: (View Article at PubMed) PMID:18789551
DOI: Full-text: DOI:10.1016/j.diabres.2008.08.001

AIM: To determine how serum concentrations of resistin are distributed in humans in relation to insulin resistance, type 2 diabetes, and obesity. METHODS: Cross-sectional, descriptive study carried out in a random sample (n=713, 43% men, 18-75 years) of general population of inhabitants of the Canary Islands (Spain). Serum resistin concentration, HOMA2-IR, anthropometric parameters, drug consumption and physical activity were recorded. RESULTS: There were no differences in resistin concentration between participants with and without diabetes (3.1+/-0.2 vs. 3.2+/-0.1ng/mL; p=0.566), or between obese and non-obese participants (3.1+/-0.1 vs. 3.2+/-0.1ng/mL; p=0.803). Individuals with abdominal obesity (waist-hip ratio [WHR] >or=1 in men or >or=0.9 in women) had lower concentrations of resistin (3.0+/-0.13 vs. 3.4+/-0.1ng/mL; p<0.001). The correlations between resistin and HOMA2-IR (r=-0.231; p<0.001) and between resistin and WHR (r=-0.202; p<0.001) were inverse. Multivariate analysis corroborated the inverse association of this cytokine with HOMA2-IR, WHR and, in women, also retained in the model the direct association between resistin and physical activity and the inverse association between resistin and antihypertensive agents. CONCLUSIONS: In this population resistin is inversely associated with insulin resistance and abdominal obesity.


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Created: 2009-09-29
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