RGD Reference Report - Retinal insulin receptor signaling in hyperosmotic stress. - Rat Genome Database

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Retinal insulin receptor signaling in hyperosmotic stress.

Authors: Rajala, RV  Ivanovic, I  Dilly, AK 
Citation: Rajala RV, etal., Vitam Horm. 2009;80:583-612.
RGD ID: 2313404
Pubmed: PMID:19251051   (View Abstract at PubMed)
PMCID: PMC2670484   (View Article at PubMed Central)
DOI: DOI:10.1016/S0083-6729(08)00620-1   (Journal Full-text)

In the diabetic eye, the increased accumulation of sorbitol in the retina has been implicated in the pathogenesis of diabetic retinopathy (DR). Neurodegeneration is an important component of DR as demonstrated by increased neural apoptosis in the retina during experimental and human diabetes. Insulin receptor (IR) activation has been shown to rescue retinal neurons from apoptosis through a phosphoinositide 3-kinase and protein kinase B (Akt) survival cascade. In this study, we examined the IR signaling in sorbitol-induced hyperosmotic stressed retinas.

Objects referenced in this article
Gene Akt2 AKT serine/threonine kinase 2 Rattus norvegicus

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