RGD Reference Report - Postprandial increase of plasma apoAV concentrations in Type 2 diabetic patients. - Rat Genome Database

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Postprandial increase of plasma apoAV concentrations in Type 2 diabetic patients.

Authors: Pruneta-Deloche, V  Ponsin, G  Groisne, L  Fruchart-Najib, J  Lagarde, M  Moulin, P 
Citation: Pruneta-Deloche V, etal., Atherosclerosis. 2005 Aug;181(2):403-5. Epub 2005 Feb 17.
RGD ID: 2313321
Pubmed: PMID:16039297   (View Abstract at PubMed)
DOI: DOI:10.1016/j.atherosclerosis.2005.01.034   (Journal Full-text)

Postprandial hypertriglyceridemia is considered as a risk factor for cardiovascular disease in Type 2 diabetes. However, little is known about the underlying mechanisms. Since the recently discovered apolipoprotein (apo) AV was identified as a modulator of triglyceride (TG) metabolism, the aim of the study was to determine the postprandial apoAV profile of Type 2 diabetic patients. We compared data from 11 patients with Type 2 diabetes mellitus to that of 12 non-diabetic normolipidemic subjects following the ingestion of a lipid-rich cream. Postprandial apoAV was elevated in diabetic patients but no correlation was observed either with plasma TG concentration or with the intensity of lipoprotein lipase-dependent lipolysis. These data obtained in human subjects suggest that plasma apoAV concentration does not play an acute or a direct role in the regulation of plasma TG in the postprandial state.

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Apoa5  (apolipoprotein A5)

Genes (Mus musculus)
Apoa5  (apolipoprotein A-V)

Genes (Homo sapiens)
APOA5  (apolipoprotein A5)

Additional Information