RGD Reference Report - Maternal serum adiponectin concentration in gestational diabetes. - Rat Genome Database

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Maternal serum adiponectin concentration in gestational diabetes.

Authors: Soheilykhah, S  Mohammadi, M  Mojibian, M  Rahimi-Saghand, S  Rashidi, M  Hadinedoushan, H  Afkhami-Ardekani, M 
Citation: Soheilykhah S, etal., Gynecol Endocrinol. 2009 Jul 16:1-4.
RGD ID: 2313236
Pubmed: PMID:19626510   (View Abstract at PubMed)
DOI: DOI:10.1080/09513590902972109   (Journal Full-text)

Aim. Adiponectin is an insulin sensitizing protein. Because gestational diabetes mellitus is associated with insulin resistance, we compared serum adiponectin levels in women with gestational diabetes mellitus and healthy pregnant women. Study design. Twenty-nine women with gestational diabetes and 26 women with impaired glucose tolerance were compared with 27 normal pregnant women in control group. Controls were matched for gestational age, age and body mass index (BMI) before pregnancy with two other groups. At 28 weeks of gestation serum concentration of adiponectin, insulin and insulin resistance (calculated by the homeostasis model assessment) were measured in three groups. Main findings. The serum adiponectin level in gestational diabetes (6379.31 +/- 1934.90 ng/ml), was significantly lower than the impaired glucose tolerance test (7384.61 +/- 1626.70 ng/ml) and control groups (7962.96 +/- 2667.20 ng/ml),(p = 0.02). Serum level of insulin and HOMA index in gestational diabetes were higher than the normal group (p > 0.05). In patients with gestational diabetes, there was a significant correlation between serum adiponectin level and BMI before pregnancy (r = -0.531, p = 0.013). Also, the correlation between maternal serum adiponectin levels and neonatal birth weight was not significant (r = -0.07, p value = 0.73). Conclusion. Our data show that serum adiponectin level was significantly lower in gestational diabetes in comparison with healthy pregnant women.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
gestational diabetes  IEP 2313236protein:decreased expression:serumRGD 
gestational diabetes  ISOADIPOQ (Homo sapiens)2313236; 2313236protein:decreased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Adipoq  (adiponectin, C1Q and collagen domain containing)

Genes (Mus musculus)
Adipoq  (adiponectin, C1Q and collagen domain containing)

Genes (Homo sapiens)
ADIPOQ  (adiponectin, C1Q and collagen domain containing)


Additional Information