RGD Reference Report - Induction of type I diabetes by Kilham's rat virus in diabetes-resistant BB/Wor rats. - Rat Genome Database

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Induction of type I diabetes by Kilham's rat virus in diabetes-resistant BB/Wor rats.

Authors: Guberski, DL  Thomas, VA  Shek, WR  Like, AA  Handler, ES  Rossini, AA  Wallace, JE  Welsh, RM 
Citation: Guberski DL, etal., Science. 1991 Nov 15;254(5034):1010-3.
RGD ID: 2313207
Pubmed: PMID:1658938   (View Abstract at PubMed)

Type I diabetes mellitus is an autoimmune disease resulting from the interaction of genetic and environmental factors. A virus that was identified serologically as Kilham's rat virus (KRV) was isolated from a spontaneously diabetic rat and reproducibly induced diabetes in naive diabetes-resistant (DR) BB/Wor rats. Viral antigen was not identified in pancreatic islet cells, and beta cell cytolysis was not observed until after the appearance of lymphocytic insulitis. KRV did not induce diabetes in major histocompatibility complex-concordant and discordant non-BB rats and did not accelerate diabetes in diabetes-prone BB/Wor rats unless the rats had been reconstituted with DR spleen cells. This model of diabetes may provide insight regarding the interaction of viruses and autoimmune disease [corrected]



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BBDR/WorBrmRattype 1 diabetes mellitus MODEL: inducedIAGPKilham rat virusKilham's rat virusRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Objects Annotated

Strains
BBDP/WorBrm  (NA)
BBDR/WorBrm  (NA)
Crl:LE  (Long-Evans Rats)
PVG  (PVG)
WF/N  (NA)


Additional Information