RGD Reference Report - Delayed P2X4R expression after hypoxia-ischemia is associated with microglia in the immature rat brain. - Rat Genome Database

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Delayed P2X4R expression after hypoxia-ischemia is associated with microglia in the immature rat brain.

Authors: Wixey, JA  Reinebrant, HE  Carty, ML  Buller, KM 
Citation: Wixey JA, etal., J Neuroimmunol. 2009 Jul 25;212(1-2):35-43. Epub 2009 May 17.
RGD ID: 2313021
Pubmed: PMID:19447505   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jneuroim.2009.04.016   (Journal Full-text)

In a preterm hypoxia-ischemia model in the post-natal day 3 rat, we characterized how the expression of purine ionotropic P2X(4) receptors change in the brain post-insult. After hypoxia-ischemia, P2X(4) receptor expression increased significantly and was associated with a late increase in ionised calcium binding adapter molecule-1 protein expression indicative of microglia cell activation. Minocycline, a potent inhibitor of microglia, attenuated the hypoxia-ischemia-induced increase in P2X(4) receptor expression. We postulate that P2X(4) receptor-positive microglia may represent a population of secondary injury-induced activated microglia. Future studies will determine whether this population contributes to the progression of injury in the immature brain.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Brain Hypoxia-Ischemia  ISOAif1 (Rattus norvegicus)2313021; 2313021protein:increased expression:right cerebral hemisphere (rat)RGD 
Brain Hypoxia-Ischemia  IEP 2313021protein:increased expression:right cerebral hemisphere (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aif1  (allograft inflammatory factor 1)

Genes (Mus musculus)
Aif1  (allograft inflammatory factor 1)

Genes (Homo sapiens)
AIF1  (allograft inflammatory factor 1)


Additional Information