RGD Reference Report - Genetic regulation of bone traits is influenced by sex and reciprocal cross in F(2) progeny from GK and F344 rats. - Rat Genome Database

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Genetic regulation of bone traits is influenced by sex and reciprocal cross in F(2) progeny from GK and F344 rats.

Authors: Lagerholm, S  Li, LS  Jiao, H  Park, HB  Ohlsson, C  Akesson, K  Luthman, H 
Citation: Lagerholm S, etal., J Bone Miner Res. 2009 Jun;24(6):1066-74.
RGD ID: 2312767
Pubmed: (View Article at PubMed) PMID:19113924
DOI: Full-text: DOI:10.1359/jbmr.081252

A genome-wide linkage analysis to identify quantitative trait loci (QTLs) for bone phenotypes was performed in an F(2) intercross of inbred spontaneously type 2 diabetic GK and normoglycemic F344 rats (108 males and 98 females). The aim of the study was to locate genome regions with candidate genes affecting trabecular and cortical bone and to investigate the effects of sex and reciprocal cross. pQCT was used to determine tibial bone phenotypes in the F(2) rats, comprising reciprocal crosses with divergent mitochondrial (mt) DNA. Sex and reciprocal cross-separated QTL analyses were performed followed by assessment of specific interactions. Four genome-wide significant QTLs linked to either cortical vBMD, tibia length, body length, or metaphyseal area were identified in males on chromosomes (chr) 1, 8, and 15. In females, three significant QTLs linked to cortical BMC or metaphyseal total vBMD were identified on chr 1 and 2. Several additional suggestive loci for trabecular and cortical traits were detected in both males and females. Four female-specific QTLs on chr 2, 3, 5, and 10 and four reciprocal cross-specific QTLs on chr 1, 10, and 18 were identified, suggesting that both sex and mt genotype influence the expression of bone phenotypes.

Annotation

Disease Annotations    
osteoporosis  (IAGP)

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Bmd69  (Bone mineral density QTL 69)
Bmd70  (Bone mineral density QTL 70)
Bmd71  (Bone mineral density QTL 71)
Bmd72  (Bone mineral density QTL 72)
Bmd73  (Bone mineral density QTL 73)
Bmd74  (Bone mineral density QTL 74)
Bmd75  (Bone mineral density QTL 75)
Bmd76  (Bone mineral density QTL 76)
Bmd77  (Bone mineral density QTL 77)
Bmd78  (Bone mineral density QTL 78)
Bmd79  (Bone mineral density QTL 79)
Bmd80  (Bone mineral density QTL 80)
Bss51  (Bone structure and strength QTL 51)
Bss52  (Bone structure and strength QTL 52)
Bss53  (Bone structure and strength QTL 53)
Bss54  (Bone structure and strength QTL 54)
Bss55  (Bone structure and strength QTL 55)
Bss56  (Bone structure and strength QTL 56)
Bss57  (Bone structure and strength QTL 57)
Bss58  (Bone structure and strength QTL 58)
Bss59  (Bone structure and strength QTL 59)
Bss60  (Bone structure and strength QTL 60)
Bss61  (Bone structure and strength QTL 61)
Bss62  (Bone structure and strength QTL 62)
Bss63  (Bone structure and strength QTL 63)
Bss64  (Bone structure and strength QTL 64)
Bss65  (Bone structure and strength QTL 65)
Bss66  (Bone structure and strength QTL 66)
Bss67  (Bone structure and strength QTL 67)
Bss68  (Bone structure and strength QTL 68)
Bss69  (Bone structure and strength QTL 69)
Bss70  (Bone structure and strength QTL 70)
Bss71  (Bone structure and strength QTL 71)
Bss72  (Bone structure and strength QTL 72)
Bss73  (Bone structure and strength QTL 73)
Bss74  (Bone structure and strength QTL 74)
Bss75  (Bone structure and strength QTL 75)
Bss76  (Bone structure and strength QTL 76)
Bss77  (Bone structure and strength QTL 77)
Bss78  (Bone structure and strength QTL 78)
Bss79  (Bone structure and strength QTL 79)
Bss80  (Bone structure and strength QTL 80)
Bss81  (Bone structure and strength QTL 81)
Bss82  (Bone structure and strength QTL 82)
Bss83  (Bone structure and strength QTL 83)
Bss84  (Bone structure and strength QTL 84)
Bss85  (Bone structure and strength QTL 85)
Bw96  (Body weight QTL 96)

Objects referenced in this article
Strain F344/DuCrlSwe null Rattus norvegicus
Strain GK/KyoSwe Goto Kakizaki Rattus norvegicus

Additional Information