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Involvement of myosin Vb in glutamate receptor trafficking.

Authors: Lise, MF  Wong, TP  Trinh, A  Hines, RM  Liu, L  Kang, R  Hines, DJ  Lu, J  Goldenring, JR  Wang, YT  El-Husseini, A 
Citation: Lise MF, etal., J Biol Chem. 2006 Feb 10;281(6):3669-78. Epub 2005 Dec 7.
Pubmed: (View Article at PubMed) PMID:16338934
DOI: Full-text: DOI:10.1074/jbc.M511725200

Myosin V motors mediate cargo transport; however, the identity of neuronal molecules transported by these proteins remains unknown. Here we show that myosin Vb is expressed in several neuronal populations and associates with the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate-type glutamate receptor subunit GluR1. In developing hippocampal neurons, expression of the tail domain of myosin Vb, but not myosin Va, enhanced GluR1 accumulation in the soma and reduced its surface expression. These changes were accompanied by reduced GluR1 clustering and diminished frequency of excitatory but not inhibitory synaptic currents. Similar effects were observed upon expression of full-length myosin Vb lacking a C-terminal region required for binding to the small GTPase Rab11. In contrast, mutant myosin Vb did not change the localization of several other neurotransmitter receptors, including the glutamate receptor subunit NR1. These results reveal a novel mechanism for the transport of a specific glutamate receptor subunit in neurons mediated by a member of the myosin V family.


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RGD Object Information
RGD ID: 2312658
Created: 2009-08-28
Species: All species
Last Modified: 2009-08-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.