RGD Reference Report - Gating of the cAMP signaling cascade and melatonin synthesis by the circadian clock in mammalian retina. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Gating of the cAMP signaling cascade and melatonin synthesis by the circadian clock in mammalian retina.

Authors: Fukuhara, C  Liu, C  Ivanova, TN  Chan, GC  Storm, DR  Iuvone, PM  Tosini, G 
Citation: Fukuhara C, etal., J Neurosci. 2004 Feb 25;24(8):1803-11.
RGD ID: 2312640
Pubmed: (View Article at PubMed) PMID:14985420
DOI: Full-text: DOI:10.1523/JNEUROSCI.4988-03.2004

Melatonin is synthesized in retinal photoreceptor cells and acts as a neuromodulator imparting photoperiodic information to the retina. The synthesis of melatonin is controlled by an ocular circadian clock and by light in a finely tuned mechanism that ensures that melatonin is synthesized and acts only at night in darkness. Here we report that the circadian clock gates melatonin synthesis in part by regulating the expression of the type 1 adenylyl cyclase (AC1) and the synthesis of cAMP in photoreceptor cells. This gating is effected through E-box-mediated transcriptional activation of the AC1 gene, which undergoes robust daily fluctuations that persist in constant illumination. The circadian control of the cAMP signaling cascade indicates that the clock has a more general and profound impact on retinal functions than previously thought. In addition, rhythmic control of AC1 expression was observed in other parts of the central circadian axis, the suprachiasmatic nucleus and pineal gland, but not in other brain areas examined. Thus, clock control of the cAMP signaling cascade may play a central role in the integration of circadian signals that control physiology and behavior.

Annotation

Gene Ontology Annotations    

Biological Process

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Adcy1  (adenylate cyclase 1)


Additional Information