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Dietary selenium requirements based on tissue selenium concentration and glutathione peroxidase activities in old female rats.

Authors: Sunde, RA  Thompson, KM 
Citation: Sunde RA and Thompson KM, J Trace Elem Med Biol. 2009;23(2):132-7. Epub 2009 Mar 14.
Pubmed: (View Article at PubMed) PMID:19398061
DOI: Full-text: DOI:10.1016/j.jtemb.2009.02.002

Dietary nutrient requirements for older animals have been studied far less than have requirements for young growing animals. To determine dietary selenium (Se) requirements in old rats, we fed female weanling rats a Se-deficient diet (0.007 microg Se/g) or supplemented rats with graded levels of dietary Se (0-0.3 microg Se/g) as Na(2)SeO(3) for 52 weeks. At no point did Se deficiency or level of Se supplementation have a significant effect (P>0.05) on growth. To determine Se requirements, Se response curves were determined for 7 Se-dependent parameters. We found that minimum dietary Se requirements in year-old female rats were at or below 0.05 microg Se/g diet based on liver Se, red blood cell glutathione peroxidase (Gpx1) activity, plasma Gpx3 activity, liver and kidney Gpx1 activity, and liver and kidney Gpx4 activity. In conclusion, this study found that dietary Se requirements in old female rats were decreased at least 50% relative to requirements found in young, rapidly growing female rats. Collectively, this indicates that the homeostatic mechanisms related to retention and maintenance of Se status are still fully functional in old female rats.


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RGD Object Information
RGD ID: 2312622
Created: 2009-08-26
Species: All species
Last Modified: 2009-08-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.