RGD Reference Report - A nuclear location for Ca2+-activated adenylyl cyclases I and III in neurones. - Rat Genome Database

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A nuclear location for Ca2+-activated adenylyl cyclases I and III in neurones.

Authors: Parkinson, NA  Bolsover, SR 
Citation: Parkinson NA and Bolsover SR, Brain Res Mol Brain Res. 2001 Jul 13;91(1-2):43-9.
RGD ID: 2312581
Pubmed: PMID:11457491   (View Abstract at PubMed)

Calcium/calmodulin-sensitive adenylyl cyclases are increasingly recognised as important factors in memory formation and synaptic plasticity. We have examined the distributions of adenylyl cyclases types I, III, and VIII within rat primary sensory neurons. Immunofluorescence revealed distinct staining for adenylyl cyclases type I and III, but not adenylyl cyclase type VIII, within the cell nucleus. Western blots suggest that a processed form of adenylyl cyclase type III may be found within primary neurons and PC12 cells as a 70-kDa protein. We propose that the observed nuclear adenylyl cyclases are soluble forms of the cyclases.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Adcy1Rataxon hillock  IDA MMO:0000686RGD 
Adcy1Ratcytoplasm  IDA MMO:0000686RGD 
Adcy1Ratnucleus  IDA MMO:0000686RGD 
Adcy3Ratnucleus  IDA MMO:0000686RGD 
Adcy8Ratplasma membrane  IDA MMO:0000686RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adcy1  (adenylate cyclase 1)
Adcy3  (adenylate cyclase 3)
Adcy8  (adenylate cyclase 8)


Additional Information