RGD Reference Report - Adiponectin, skeletal muscle adiponectin receptor expression and insulin resistance following dexamethasone. - Rat Genome Database

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Adiponectin, skeletal muscle adiponectin receptor expression and insulin resistance following dexamethasone.

Authors: Jang, C  Inder, WJ  Obeyesekere, VR  Alford, FP 
Citation: Jang C, etal., Clin Endocrinol (Oxf). 2008 Nov;69(5):745-50. Epub 2008 Mar 15.
RGD ID: 2312486
Pubmed: PMID:18363889   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1365-2265.2008.03242.x   (Journal Full-text)

OBJECTIVE: Skeletal muscle is a major site of adiponectin action and of glucocorticoid-induced insulin resistance. Little human data exist however, regarding the impact of exogenous glucocorticoids on adiponectin receptors in skeletal muscle. DESIGN AND PATIENTS: Twelve subjects with type 2 diabetes and 12 controls underwent blood sampling and muscle biopsy of vastus lateralis before and after 4 days of 4 mg dexamethasone. MEASUREMENTS: (i) Total and high molecular weight (HMW) plasma adiponectin, glucose and insulin; (ii) Skeletal muscle adiponectin receptor AdipoR1 and AdipoR2 mRNA levels by quantitative real time RT-PCR. RESULTS: Baseline total adiponectin (8.0 +/- 0.89 vs. 12.5 +/- 1.46 microg/ml, P = 0.013), HMW adiponectin (2.8 +/- 0.44 vs. 5.9 +/- 1.04 microg/ml, P = 0.014) and AdipoR2 mRNA levels (mean DeltaC(T )14.71 +/- 0.35 vs. 13.37 +/- 0.28, P = 0.017) were significantly lower in diabetic subjects. After dexamethasone, AdipoR2 mRNA fell in the controls but there was no change in the diabetic group, while there was a significant increase in total (P = 0.002) and HMW adiponectin (P < 0.001) across both groups. Total and HMW plasma adiponectin correlated with clinical and biochemical measures of insulin sensitivity. However following dexamethasone which increased insulin resistance, the relationship between adiponectin and the biochemical measures was lost. CONCLUSIONS: Plasma adiponectin and skeletal muscle AdipoR2 mRNA expression are reduced in subjects with diabetes; both are likely to contribute to the observed insulin resistance. Dexamethasone inhibits AdipoR2 mRNA expression in nondiabetic subjects, while there is a small rise in plasma adiponectin levels. The close relationship between plasma adiponectin and biochemical measures of insulin sensitivity is lost in the setting of glucocorticoid-induced insulin resistance.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 2 diabetes mellitus  IDA 2312486Reduced expression of ADIPOR2 mRNA in muscle and which may contribute to insulin resistanceRGD 
type 2 diabetes mellitus  ISOADIPOR2 (Homo sapiens)2312486 RGD 
type 2 diabetes mellitus  ISOADIPOR2 (Homo sapiens)2312486Reduced ADIPOR2 mRNA in muscle and may contribute to insulin resistanceRGD 

Objects Annotated

Genes (Rattus norvegicus)
Adipor2  (adiponectin receptor 2)

Genes (Mus musculus)
Adipor2  (adiponectin receptor 2)

Genes (Homo sapiens)
ADIPOR2  (adiponectin receptor 2)


Additional Information