RGD Reference Report - Risk factors for thromboembolic events in renal failure. - Rat Genome Database

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Risk factors for thromboembolic events in renal failure.

Authors: D'Elia, JA  Weinrauch, LA  Gleason, RE  Lipinska, I  Lipinski, B  Lee, AT  Tofler, GH 
Citation: D'Elia JA, etal., Int J Cardiol. 2005 May 11;101(1):19-25.
RGD ID: 2312383
Pubmed: PMID:15860378   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ijcard.2004.03.007   (Journal Full-text)

OBJECTIVES: To determine whether prior thromboembolic events (TE) influence current measures of hemostasis, inflammation and oxidative stress in a population at high cardiovascular risk. BACKGROUND: Renal failure patients demonstrate a remarkably elevated incidence of TE. METHODS: Relationships between plasma test results and prior TE history were studied in 78 diabetic and 23 non-diabetic patients with renal failure. TE were defined as myocardial infarction, stroke or vascular surgery. RESULTS: Markers for inflammation (interleukin (IL)-6, C reactive protein (CRP)), thrombosis (fibrinogen, low molecular weight (LMW) fibrinogen, factor VII, viscosity), fibrinolysis (fibrinolytic activity, plasminogen activator inhibitor (PAI)), endothelial/platelet activity (P-selectin, von Willebrand factor (vWf)) and oxidative stress (antibody to oxidized low-density lipoprotein (LDL), advanced glycated end products) were significantly different from a healthy control population. Dialysis patients with diabetes were twice as likely to have sustained a TE (58 vs. 30%, p = 0.032). Those patients in the total group with levels above the median for IL-6 (p = 0.045), and CRP (p < 0.017) were more likely to have sustained a TE than those with levels below the median. Those diabetic patients with levels above the median for CRP were more likely to have a prior history of TE (p < 0.021). For non-diabetic patients, levels above the median of IL-6 were associated with a prior history of TE (p = 0.027). Multiple correlations for factors of inflammation, hemostasis and oxidative stress indicate that these mechanisms are not independent of one another. CONCLUSION: Prior TE was associated with markers of inflammation a relationship that may influence the interpretation of these tests which are strongly interrelated in patients at high cardiovascular risk.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 1 diabetes mellitus  ISOF7 (Homo sapiens)2312383; 2312383associated with Kidney Failure and protein:increased expression:plasma (human)RGD 
type 1 diabetes mellitus  IEP 2312383associated with Kidney Failure and protein:increased expression:plasma (human)RGD 
type 2 diabetes mellitus  ISOF7 (Homo sapiens)2312383; 2312383associated with Kidney Failure and protein:increased expression:plasma (human)RGD 
type 2 diabetes mellitus  IEP 2312383associated with Kidney Failure and protein:increased expression:plasma (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
F7  (coagulation factor VII)

Genes (Mus musculus)
F7  (coagulation factor VII)

Genes (Homo sapiens)
F7  (coagulation factor VII)


Additional Information