RGD Reference Report - Circadian rhythms of blood clotting time and coagulation factors II, VII, IX and X in rats. - Rat Genome Database

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Circadian rhythms of blood clotting time and coagulation factors II, VII, IX and X in rats.

Authors: Soulban, G  Labrecque, G 
Citation: Soulban G and Labrecque G, Life Sci. 1989;45(25):2485-9.
RGD ID: 2312319
Pubmed: PMID:2607889   (View Abstract at PubMed)

The 24-hr variations in clotting times and vitamin K-dependent blood coagulation factors were studied in rats kept on a 12-hr light-dark cycle (light on: 0600-1800 hours). Clotting times were determined under a binocular microscope by measuring the time required for the formation of the first fibrin thread. Factors II, VII and X were analyzed by the prothrombin test while the factor IX was quantified using the activated partial thromboplastin time assay. Results indicated that the clotting times were significantly longer during the dark (activity) period with a peak at 1:00 and a trough at 17:00. Similarly, a variation was found in factor activity levels: prothrombin (II), factor VII and factor X had higher activities during the light span (rest period). The highest activities found at 13:00 and 09:00 were statistically different from the minimum activity levels obtained at 21:00. Factor IX did not show a significant circadian variation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
circadian rhythm  IEP 2312319 RGD 

Objects Annotated

Genes (Rattus norvegicus)
F7  (coagulation factor VII)


Additional Information