RGD Reference Report - Asp905Tyr polymorphism of the gene for the skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in NIDDM. - Rat Genome Database

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Asp905Tyr polymorphism of the gene for the skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in NIDDM.

Authors: Shen, GQ  Ikegami, H  Kawaguchi, Y  Fujisawa, T  Hamada, Y  Ueda, H  Shintani, M  Nojima, K  Kawabata, Y  Yamada, K  Babaya, N  Ogihara, T 
Citation: Shen GQ, etal., Diabetes Care. 1998 Jul;21(7):1086-9.
RGD ID: 2311515
Pubmed: PMID:9653600   (View Abstract at PubMed)

OBJECTIVE: To clarify the contribution of the Asp905Tyr polymorphism of the muscle-specific glycogen-targeting subunit of protein phosphatase 1 (PP1G) to insulin resistance and related diseases. RESEARCH DESIGN AND METHODS: We investigated the Asp905Tyr polymorphism of the PPP1R3 gene, which encodes the muscle-specific glycogen-targeting subunit of PP1G, in 259 Japanese patients with NIDDM and 194 healthy control subjects. RESULTS: No significant difference was found in the genotype distribution between NIDDM patients (N = 259; Asp/Asp = 0.10, Asp/Tyr = 0.44, Tyr/Try = 0.46) and healthy control subjects (n = 194; Asp/Asp = 0.13, Asp/Tyr = 0.37, Tyr/Tyr = 0.50) or between patient groups subdivided by the mode of treatment: NIDDM patients with insulin therapy (Asp/Asp = 0.14, Asp/Tyr = 0.46, Tyr/Tyr = 0.40) and those without insulin therapy (Asp/Asp = 0.07, Asp/Tyr = 0.43, Tyr/Tyr = 0.50). However, NIDDM patients with the Tyr allele, which was previously reported to be associated with insulin resistance, tended to have lower BMIs than those without this allele (Asp/Asp: 24.5 +/- 1.1 kg/m2, Asp/Tyr: 22.6 +/- 0.4 kg/m2, Tyr/Tyr: 22.8 + 0.3 kg/m2, P = 0.06 by analysis of variance). CONCLUSIONS: These data suggest that the Asp905Tyr polymorphism of the PPP1R3 gene is not associated with NIDDM or high BMI, both of which are known to be insulin-resistant states, in the Japanese population.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 2 diabetes mellitus no_associationIAGP 2311515DNA:missense mutation: :p.D905Y (human)RGD 
type 2 diabetes mellitus no_associationISOPPP1R3A (Homo sapiens)2311515; 2311515DNA:missense mutation: :p.D905Y (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ppp1r3a  (protein phosphatase 1, regulatory subunit 3A)

Genes (Mus musculus)
Ppp1r3a  (protein phosphatase 1, regulatory subunit 3A)

Genes (Homo sapiens)
PPP1R3A  (protein phosphatase 1 regulatory subunit 3A)


Additional Information