RGD Reference Report - Inhibition of endoplasm reticulum stress by ghrelin protects against ischemia/reperfusion injury in rat heart. - Rat Genome Database

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Inhibition of endoplasm reticulum stress by ghrelin protects against ischemia/reperfusion injury in rat heart.

Authors: Zhang, GG  Teng, X  Liu, Y  Cai, Y  Zhou, YB  Duan, XH  Song, JQ  Shi, Y  Tang, CS  Yin, XH  Qi, YF 
Citation: Zhang GG, etal., Peptides. 2009 Jun;30(6):1109-16. Epub 2009 May 3.
RGD ID: 2311458
Pubmed: PMID:19406177   (View Abstract at PubMed)
DOI: DOI:10.1016/j.peptides.2009.03.024   (Journal Full-text)

Ghrelin is a multi-functional polypeptide with cardiovascular protective effects. We aimed to explore whether the cardioprotective effect of ghrelin is mediated by inhibiting myocardial endoplasmic reticulum stress (ERS). A Langendorff model of isolated rat heart was used with ischemia/reperfusion (I/R; 40/120 min). Cardiac function was monitored, and histomorphologic features, degree of myocardial injury, level of ERS markers, and number of apoptotic cardiomyocytes were determined. Compared with control group, the I/R group showed significantly decreased cardiac function, seriously damaged myocardial tissue, increased number of apoptotic cells, and overexpression of mRNA and protein of ERS markers. However, preadministration of ghrelin in vivo (10(-8)mol/kg, intraperitoneal injection, every 12h, twice in all) greatly ameliorated the damaged heart function, attenuated myocardial injury and apoptosis, and decreased the expression of ERS markers: it decreased the mRNA and protein levels of glucose-regulated protein78 (GRP78) and C/EBP homologous protein (CHOP), with reduced caspase-12 protein expression. Furthermore, in vitro, ghrelin directly inhibited the myocardial ERS response induced by tunicamycin or dithiothreitol in rat cardiac tissue. Ghrelin could protect the heart against I/R injury, at least in part, through inhibiting myocardial ERS.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Myocardial Reperfusion Injury  ISOCasp12 (Rattus norvegicus)2311458; 2311458protein:increased activity:myocardiumRGD 
Myocardial Reperfusion Injury  IEP 2311458protein:increased activity:myocardiumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Casp12  (caspase 12)

Genes (Mus musculus)
Casp12  (caspase 12)

Genes (Homo sapiens)
CASP12  (caspase 12 (gene/pseudogene))


Additional Information