RGD Reference Report - Chronic CXCL10 alters the level of activated ERK1/2 and transcriptional factors CREB and NF-kappaB in hippocampal neuronal cell culture. - Rat Genome Database

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Chronic CXCL10 alters the level of activated ERK1/2 and transcriptional factors CREB and NF-kappaB in hippocampal neuronal cell culture.

Authors: Bajova, H  Nelson, TE  Gruol, DL 
Citation: Bajova H, etal., J Neuroimmunol. 2008 Mar;195(1-2):36-46. Epub 2008 Mar 10.
RGD ID: 2311378
Pubmed: PMID:18329727   (View Abstract at PubMed)
PMCID: PMC2396565   (View Article at PubMed Central)
DOI: DOI:10.1016/j.jneuroim.2008.01.003   (Journal Full-text)

Signal transduction pathways may be important targets of chemokines during neuroinflammation. In the current study, Western blot analyses show that in rat hippocampal neuronal/glial cell cultures chronic CXCL10 increases the level of protein for ERK1/2 as well as for the transcriptional factors CREB and NF-kappaB. Bcl-2, an anti-apoptotic protein whose expression can be regulated by a pathway involving ERK1/2, CREB and NF-kappaB, was also increased in the CXCL10 treated cultures. These results implicate a role for ERK1/2, CREB and NF-kappaB in effects of CXCL10 on hippocampal cells and suggest that chronic CXCL10 may have a protective role during certain neuroinflammatory conditions.

Objects referenced in this article
Gene Cxcl10 C-X-C motif chemokine ligand 10 Rattus norvegicus

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