RGD Reference Report - alpha-Cell neogenesis in an animal model of IDDM. - Rat Genome Database

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alpha-Cell neogenesis in an animal model of IDDM.

Authors: O'Reilly, LA  Gu, D  Sarvetnick, N  Edlund, H  Phillips, JM  Fulford, T  Cooke, A 
Citation: O'Reilly LA, etal., Diabetes. 1997 Apr;46(4):599-606.
RGD ID: 2311221
Pubmed: PMID:9075799   (View Abstract at PubMed)

Currently there is debate regarding the capacity of pancreatic islets to regenerate in adult animals. Because pancreatic endocrine cells are thought to arise from duct cells, we examined the pancreatic ductal epithelium of the diabetic NOD mouse for evidence of islet neogenesis. We have evidence of duct proliferation as well as ductal cell differentiation, as suggested by bromodeoxyuridine-labeling and the presence of glucagon-containing cells within these ducts. In addition, the ductal epithelia in diabetic NOD mice expressed the neuroendocrine markers neuropeptide Y and tyrosine hydroxylase. These ducts also expressed the homeobox gene product, insulin promoter factor 1. Ductal cell proliferation and expression of these markers was not observed in transgenic NOD mice (NOD-E), which do not develop clinical or histopathological symptoms of IDDM. This suggests that the observed ductal cell proliferation and differentiation was a direct result of beta-cell destruction and insulin insufficiency in these adult diabetic mice, which further suggests that these events are recapitulating islet ontogeny observed during embryogenesis. It is possible that comparable processes occur in the human diabetic pancreas.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 2 diabetes mellitus  ISOPdx1 (Mus musculus)2311221; 2311221protein:increased expression:pancreatic duct (mouse)RGD 
type 2 diabetes mellitus  IEP 2311221protein:increased expression:pancreatic duct (mouse)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pdx1  (pancreatic and duodenal homeobox 1)

Genes (Mus musculus)
Pdx1  (pancreatic and duodenal homeobox 1)

Genes (Homo sapiens)
PDX1  (pancreatic and duodenal homeobox 1)


Additional Information