RGD Reference Report - Lowered expressions of the NF-kappaB family members in dendritic cells from NOD mice are associated with a reduced expression of GATA-2. - Rat Genome Database

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Lowered expressions of the NF-kappaB family members in dendritic cells from NOD mice are associated with a reduced expression of GATA-2.

Authors: Takahashi, K  Satoh, J  Oka, Y 
Citation: Takahashi K, etal., Ann N Y Acad Sci. 2008 Dec;1150:59-60.
RGD ID: 2307278
Pubmed: PMID:19120268   (View Abstract at PubMed)
DOI: DOI:10.1196/annals.1447.008   (Journal Full-text)

In type 1 diabetes, dendritic cells (DCs) display defective phenotype and function and possibly play crucial roles in the pathogenesis of this disease. In the present study, we compared transcription profiles of CD11c(+) bone marrow (BM)-derived DCs from NOD mice with those from NON mice, focusing on the NF-kappaB/Rel family members and associated molecules. The BMDCs from NOD mice displayed reduced mRNA expressions of NF-kappaB components, p65, p50, p52, and RelB, compared to NON mice: the proportions of each molecule relative to those of NON DCs were 53.9, 54.1, 54.0, and 37.0%, respectively, which were accompanied with lowered expressions of downstream immunomodulatory molecules, including IL-6, CD80, CD86, 4-1BB, and CD40. The reduction of NF-kappaB components possibly underlies the defective phenotype and function of DCs from NOD mice, and could predispose to autoimmunity.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
diabetes mellitus  ISOIl6 (Mus musculus)2307278; 2307278mRNA:decreased expression:dendritic cell (mouse)RGD 
diabetes mellitus  IDA 2307278mRNA:decreased expression:dendritic cell (mouse)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il6  (interleukin 6)

Genes (Mus musculus)
Il6  (interleukin 6)

Genes (Homo sapiens)
IL6  (interleukin 6)


Additional Information