RGD Reference Report - Anti-CD38 autoimmunity in children with newly diagnosed type 1 diabetes mellitus. - Rat Genome Database

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Anti-CD38 autoimmunity in children with newly diagnosed type 1 diabetes mellitus.

Authors: Pupilli, C  Antonelli, A  Iughetti, L  D'Annunzio, G  Cotellessa, M  Vanelli, M  Okamoto, H  Lorini, R  Ferrannini, E 
Citation: Pupilli C, etal., J Pediatr Endocrinol Metab. 2005 Dec;18(12):1417-23.
RGD ID: 2307230
Pubmed: PMID:16459468   (View Abstract at PubMed)

AIMS: To test for anti-CD38 autoimmunity in children with newly-diagnosed type 1 diabetes mellitus (DM1). METHODS: Serum anti-CD38 autoantibodies were detected by Western blot in 270 children (130 girls, 140 boys, mean age 8 +/- 4 years) with newly-diagnosed DM1 and 179 gender- and age-matched non-diabetic children. In 126 diabetic children, another blood sample was obtained 15 +/- 4 months after the diagnosis. RESULTS: Anti-CD38 autoantibody titers at least 3 SD above the mean value for the control group were found in 4.4% of children with DM1 vs 0.6% of controls (chi2 = 5.8, p <0.016). No statistical differences were observed between anti-CD38 positive and negative patients in terms of phenotype. At follow-up, of six diabetic children who were positive for anti-CD38 antibodies, two were new cases. A positive correlation was found between the antibody titer of diabetic sera at diagnosis and follow up (r = 0.46, p <0.0001). CONCLUSION: An autoimmune reaction against CD38, a protein expressed in human islets, is associated with newly-diagnosed DM1. In children with DM1, CD38 autoimmunity increases with time and persists.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 1 diabetes mellitus  IDA 2307230 RGD 
type 1 diabetes mellitus  ISOCD38 (Homo sapiens)2307230; 2307230 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd38  (CD38 molecule)

Genes (Mus musculus)
Cd38  (CD38 antigen)

Genes (Homo sapiens)
CD38  (CD38 molecule)


Additional Information