RGD Reference Report - Cardiovascular effects of urotensin II in different brain areas. - Rat Genome Database

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Cardiovascular effects of urotensin II in different brain areas.

Authors: Lu, Y  Zou, CJ  Huang, DW  Tang, CS 
Citation: Lu Y, etal., Peptides. 2002 Sep;23(9):1631-5.
RGD ID: 2306871
Pubmed: (View Article at PubMed) PMID:12217424

It has been shown that intracerebroventricular injection of urotensin II (UII)-induced hypotensive and bradycardiac responses. Here, we tested the cardiovascular roles of UII in different brain areas by microinjection of UII into the A1 and A2 areas (noradrenergic cells found in the lower part of the medulla that have been designated either A1 or A2 areas), the paraventricular and the arcuate nucleus. In urethane-anaesthetized rats, we observed that: (1) microinjection of UII into the A1 area induced dose-related depressor and bradycardiac responses; (2) mean arterial blood pressure (mABP) and heart rate (HR) did not change significantly after microinjection of UII into the A2 area; and (3) significant increases in mABP and HR were induced after microinjection of 10 pmol UII into either the paraventricular or arcuate nucleus. The above results suggest that UII, in different brain areas, plays different roles in cardiovascular regulation and the A1 area is a very important action site for UII in cardiovascular regulation.

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Uts2  (urotensin 2)

Additional Information