RGD Reference Report - The effect of adrenergic agonists and antagonists on cysteine-proteinase inhibitor (cystatin) in rat saliva. - Rat Genome Database

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The effect of adrenergic agonists and antagonists on cysteine-proteinase inhibitor (cystatin) in rat saliva.

Authors: Bedi, GS 
Citation: Bedi GS Arch Oral Biol. 1991;36(8):611-8.
RGD ID: 2306749
Pubmed: PMID:1685882   (View Abstract at PubMed)

The effect of a number of adrenergic agonists and antagonists on the induction of rat salivary cystatin was investigated. A highly sensitive and specific radioimmunoassay was used to determine cystatin in rat whole saliva. Treatment for 10 consecutive days with a non-specific beta-adrenergic agonist isoproterenol, or the beta 1-adrenergic agonists dobutamine or methoxyphenamine, resulted in the induction of the salivary cystatin. Induction was also found in rats treated for 10 days with arterenol. Only trace quantities of cystatin could be detected in saliva of rats treated with the beta 2-adrenergic agonists terbutaline or salbutamol. When isoproterenol was injected concomitantly with the mixed beta-antagonist propranolol or the beta 1-adrenergic antagonists metaprolol, proctocol or atenolol the production of cystatin was totally suppressed. However, the beta 2-antagonist, ICI 118551, produced only a partial reduction in salivary cystatin induction elicited by isoproterenol. The findings suggest that the induction of salivary cystatin is regulated, in part, by beta 1-adrenergic receptor stimulation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to hormone  IEP 2306749ArterenolRGD 
response to xenobiotic stimulus  IEP 2306749methoxyphenamineRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cyss  (cystatin S)


Additional Information