RGD Reference Report - Potential participation of cystatin C in rapid eye movement sleep (REMS) modulation. - Rat Genome Database

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Potential participation of cystatin C in rapid eye movement sleep (REMS) modulation.

Authors: Gonzalez-Rivera, R  Navarro, L  Martinez-Vargas, M  Guzman-Vasquez, K  Leon-Rosario, P  Landa, A  Prospero-Garcia, O 
Citation: Gonzalez-Rivera R, etal., Neurosci Lett. 2006 Nov 20;408(3):178-82. Epub 2006 Oct 5.
RGD ID: 2306498
Pubmed: PMID:17027151   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neulet.2006.08.087   (Journal Full-text)

It has been hypothesized that proteins modulate rapid eye movement sleep (REMS). Studies have shown an increase in the liberation of proteins in the mesencephalic reticular formation of cats during REMS. It has also been determined that protein-synthesis inhibitors diminish REMS and that protease-inhibitors increase this sleep phase. These and other studies support the importance of "di novo" protein molecules in sleep, and in particular, in REMS regulation. In this context, it is important to determine the role of endogenous proteases and their endogenous inhibitors in sleep regulation. In this study, we found that Cystatin C (CC), an endogenous protease inhibitor, diminishes wakefulness and increases REMS. We have also found an increase in CC expression after REMS deprivation and a tendency to decrease after a 2 h period of REMS rebound. We further showed that REMS deprivation increases the expression of Cathepsin H (CH), a protease inhibited by CC. These results suggest that naturally occurring protease-inhibitors enhance REMS, perhaps by facilitating the availability of proteins.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Sleep Deprivation  ISOCst3 (Rattus norvegicus)2306498; 2306498 RGD 
Sleep Deprivation  ISOCtsh (Rattus norvegicus)2306498; 2306498 RGD 
Sleep Deprivation  IEP 2306498; 2306498 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cst3  (cystatin C)
Ctsh  (cathepsin H)

Genes (Mus musculus)
Cst3  (cystatin C)
Ctsh  (cathepsin H)

Genes (Homo sapiens)
CST3  (cystatin C)
CTSH  (cathepsin H)

Additional Information