RGD Reference Report - Functional compartmentalization of endosomal trafficking for the synaptic delivery of AMPA receptors during long-term potentiation. - Rat Genome Database

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Functional compartmentalization of endosomal trafficking for the synaptic delivery of AMPA receptors during long-term potentiation.

Authors: Brown, TC  Correia, SS  Petrok, CN  Esteban, JA 
Citation: Brown TC, etal., J Neurosci. 2007 Nov 28;27(48):13311-5.
RGD ID: 2306457
Pubmed: PMID:18045925   (View Abstract at PubMed)
PMCID: PMC6673392   (View Article at PubMed Central)
DOI: DOI:10.1523/JNEUROSCI.4258-07.2007   (Journal Full-text)

Endosomal membrane trafficking in dendritic spines is important for proper synaptic function and plasticity. However, little is known about the molecular identity and functional compartmentalization of the membrane trafficking machinery operating at the postsynaptic terminal. Here we report that the transport of AMPA-type glutamate receptors into synapses occurs in two discrete steps, and we identify the specific endosomal functions that control this process during long-term potentiation. We found that Rab11-dependent endosomes translocate AMPA receptors from the dendritic shaft into spines. Subsequently, an additional endosomal trafficking step, controlled by Rab8, drives receptor insertion into the synaptic membrane. Separate from this receptor delivery route, we show that Rab4 mediates a constitutive endosomal recycling within the spine. This Rab4-dependent cycling is critical for maintaining spine size but does not influence receptor transport. Therefore, our data reveal a highly compartmentalized endosomal network within the spine and identify the molecular components and functional organization of the membrane organelles that mediate AMPA receptor synaptic delivery during plasticity.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
glutamatergic synapse is_active_inIDA 2306457; 2306457PMID:18045925SynGO 
glutamatergic synapse is_active_inIMP 2306457; 2306457PMID:18045925SynGO 
Schaffer collateral - CA1 synapse is_active_inIDA 2306457PMID:18045925SynGO 
Schaffer collateral - CA1 synapse is_active_inIMP 2306457PMID:18045925SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Rab11a  (RAB11a, member RAS oncogene family)
Rab8a  (RAB8A, member RAS oncogene family)


Additional Information