RGD Reference Report - Establishment of Cre/LoxP recombination system in transgenic rats. - Rat Genome Database

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Establishment of Cre/LoxP recombination system in transgenic rats.

Authors: Sato, Y  Endo, H  Ajiki, T  Hakamata, Y  Okada, T  Murakami, T  Kobayashi, E 
Citation: Sato Y, etal., Biochem Biophys Res Commun. 2004 Jul 9;319(4):1197-202.
RGD ID: 2304190
Pubmed: PMID:15194493   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2004.04.204   (Journal Full-text)

The rat has offered an important animal model in biomedical research including surgical procedure. However, advanced genetic manipulation has progressed less far in the rat than in the mouse. Here we report the Cre/LoxP transgenic rat system, demonstrating conditional chromosomal translocation both in the fertilization and adult stage, spatio-temporal gene controlling by catheter-based adenoviral gene transfer, and muscular fusion events in the limb transplant. Taking advantage of the larger body size of the rat than the mouse, this rat system provides a potential value to evaluate biomedical and therapeutic significance for gene therapy and regenerative medicine.



Objects referenced in this article
Strain W-Tg(CAG-cre)81Jmsk null Rattus norvegicus
Strain W-Tg(CAG-DsRed2/GFP)15Jmsk null Rattus norvegicus
Strain W-Tg(CAG-DsRed2/GFP)1Jmsk null Rattus norvegicus

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