RGD Reference Report - Effects of oxytocin on GABA signalling in the foetal brain during delivery. - Rat Genome Database

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Effects of oxytocin on GABA signalling in the foetal brain during delivery.

Authors: Khazipov, R  Tyzio, R  Ben-Ari, Y 
Citation: Khazipov R, etal., Prog Brain Res. 2008;170:243-57.
RGD ID: 2304092
Pubmed: (View Article at PubMed) PMID:18655887
DOI: Full-text: DOI:10.1016/S0079-6123(08)00421-4

Oxytocin (OXT) exerts multiple effects in the adult central nervous system. However, little is known about the effects of OXT on foetal neurons during delivery, at the time when a surge of OXT occurs. In a recent study, the effects of OXT on gamma-aminobutyric acid (GABA) signalling have been reported in foetal and newborn rats. In the immature rat hippocampal and neocortical neurons at birth, endogenous OXT induced a switch in the action of GABA from excitatory to inhibitory. This excitatory-to-inhibitory switch was caused by a switch in the polarity of the GABAergic responses from depolarizing to hyperpolarizing, reflecting a decrease in the intracellular chloride concentration. The effects of OXT were mimicked and occluded by bumetanide, a selective blocker of the chloride co-transporter NKCC1, suggesting that the effects of OXT involve inhibition of NKCC1. Neuronal death caused by anoxic-aglycaemic episodes was substantially delayed in the foetal hippocampus by endogenous OXT. These findings suggest that OXT plays important role in the preparation of the foetal brain to delivery.

Disease Annotations    
Hypoxia  (IMP,ISO)

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Oxtr  (oxytocin receptor)

Genes (Mus musculus)
Oxtr  (oxytocin receptor)

Genes (Homo sapiens)
OXTR  (oxytocin receptor)

Additional Information