RGD Reference Report - betaA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development. - Rat Genome Database

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betaA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development.

Authors: Sinha, D  Klise, A  Sergeev, Y  Hose, S  Bhutto, IA  Hackler L, JR  Malpic-Llanos, T  Samtani, S  Grebe, R  Goldberg, MF  Hejtmancik, JF  Nath, A  Zack, DJ  Fariss, RN  McLeod, DS  Sundin, O  Broman, KW  Lutty, GA  Zigler JS, JR 
Citation: Sinha D, etal., Mol Cell Neurosci. 2008 Jan;37(1):85-95. Epub 2007 Aug 31.
RGD ID: 2303652
Pubmed: PMID:17931883   (View Abstract at PubMed)
PMCID: PMC4943342   (View Article at PubMed Central)
DOI: DOI:10.1016/j.mcn.2007.08.016   (Journal Full-text)

Vascular remodeling is a complex process critical to development of the mature vascular system. Astrocytes are known to be indispensable for initial formation of the retinal vasculature; our studies with the Nuc1 rat provide novel evidence that these cells are also essential in the retinal vascular remodeling process. Nuc1 is a spontaneous mutation in the Sprague-Dawley rat originally characterized by nuclear cataracts in the heterozygote and microphthalmia in the homozygote. We report here that the Nuc1 allele results from mutation of the betaA3/A1-crystallin gene, which in the neural retina is expressed only in astrocytes. We demonstrate striking structural abnormalities in Nuc1 astrocytes with profound effects on the organization of intermediate filaments. While vessels form in the Nuc1 retina, the subsequent remodeling process required to provide a mature vascular network is deficient. Our data implicate betaA3/A1-crystallin as an important regulatory factor mediating vascular patterning and remodeling in the retina.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CRYBA1Humancataract  ISOCryba1 (Rattus norvegicus) RGD 
Cryba1Ratcataract  IMP  RGD 
Cryba1Mousecataract  ISOCryba1 (Rattus norvegicus) RGD 
Cryba1Nuc1DbsaRatcataract  IMP  RGD 
SD-Cryba1Nuc1DbsaRatcataract  IMP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Objects Annotated

Genes (Rattus norvegicus)
Cryba1  (crystallin, beta A1)
Cryba1Nuc1Dbsa  (crystallin, beta A1;Nuc1 mutant, Dbsa)

Genes (Mus musculus)
Cryba1  (crystallin, beta A1)

Genes (Homo sapiens)
CRYBA1  (crystallin beta A1)

Strains
SD-Cryba1Nuc1Dbsa  (NA)


Additional Information