RGD Reference Report - Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11. - Rat Genome Database

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Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.

Authors: Spoelgen, R  Adams, KW  Koker, M  Thomas, AV  Andersen, OM  Hallett, PJ  Bercury, KK  Joyner, DF  Deng, M  Stoothoff, WH  Strickland, DK  Willnow, TE  Hyman, BT 
Citation: Spoelgen R, etal., Neuroscience. 2008 Nov 8.
RGD ID: 2303612
Pubmed: PMID:19047013   (View Abstract at PubMed)
PMCID: PMC2709796   (View Article at PubMed Central)
DOI: DOI:10.1016/j.neuroscience.2008.10.061   (Journal Full-text)

In this study, we examined protein-protein interactions between two neuronal receptors, low density lipoprotein receptor-related protein (LRP) and sorLA/LR11, and found that these receptors interact, as indicated by three independent lines of evidence: co-immunoprecipitation experiments on mouse brain extracts and mouse neuronal cells, surface plasmon resonance analysis with purified human LRP and sorLA, and fluorescence lifetime imaging microscopy (FLIM) on rat primary cortical neurons. Immunocytochemistry experiments revealed widespread co-localization of LRP and sorLA within perinuclear compartments of rat primary neurons, while FLIM analysis showed that LRP-sorLA interactions take place within a subset of these compartments.

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Gene Lrp5 LDL receptor related protein 5 Rattus norvegicus

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