RGD Reference Report - Work-induced changes in skeletal muscle IGF-1 and myostatin gene expression in uremia. - Rat Genome Database

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Work-induced changes in skeletal muscle IGF-1 and myostatin gene expression in uremia.

Authors: Sun, DF  Chen, Y  Rabkin, R 
Citation: Sun DF, etal., Kidney Int. 2006 Jun 28.
RGD ID: 2303558
Pubmed: PMID:16871256   (View Abstract at PubMed)

Resistance to growth hormone (GH)-induced insulin-like growth factor-1 (IGF-1) gene expression contributes to uremic muscle wasting. Since exercise stimulates muscle IGF-1 expression independent of GH, we tested whether work overload (WO) could increase skeletal muscle IGF-1 expression in uremia and thus bypass the defective GH action. Furthermore, to provide insight into the mechanism of uremic wasting and the response to exercise we examined myostatin expression. Unilateral plantaris muscle WO was initiated in uremic and pairfed (PF) normal rats by ablation of a gastrocnemius tendon and adjoining part of this muscle with the contralateral plantaris as a control. Some rats were GH treated for 7 days. WO led to similar gains in plantaris weight in both groups and corrected the uremic muscle atrophy. GH increased plantaris IGF-1 mRNA >twofold in PF rats but the response in uremia was severely attenuated. WO increased the IGF-1 mRNA levels significantly in both uremic and PF groups, albeit less brisk in uremia; however, after 7 days IGF-1 mRNA levels were elevated similarly, >2-fold, in both groups. In the atrophied uremic plantaris muscle basal myostatin mRNA levels were increased significantly and normalized after an increase in WO suggesting a myostatin role in the wasting process. In the hypertrophied uremic left ventricle the basal myostatin mRNA levels were reduced and likely favor the cardiac hypertrophy. Together the findings provide insight into the mechanisms of skeletal muscle wasting in uremia and the hypertrophic response to exercise, and suggest that alterations in the balance between IGF-1 and myostatin play an important role in these processes.Kidney International advance online publication, 28 June 2006; doi:10.1038/sj.ki.5001532.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MSTNHumanuremia  ISOMstn (Rattus norvegicus)associated with Kidney Failure and ChronicRGD 
MstnRaturemia  IEP associated with Kidney Failure and ChronicRGD 
MstnMouseuremia  ISOMstn (Rattus norvegicus)associated with Kidney Failure and ChronicRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mstn  (myostatin)

Genes (Mus musculus)
Mstn  (myostatin)

Genes (Homo sapiens)
MSTN  (myostatin)


Additional Information