RGD Reference Report - Peripheral venous occlusion causing cardiac hypertrophy and changes in biological parameters in rats. - Rat Genome Database

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Peripheral venous occlusion causing cardiac hypertrophy and changes in biological parameters in rats.

Authors: Kawada, S  Ishii, N 
Citation: Kawada S and Ishii N, Eur J Appl Physiol. 2009 Jan 6.
RGD ID: 2303544
Pubmed: PMID:19125275   (View Abstract at PubMed)
DOI: DOI:10.1007/s00421-008-0977-2   (Journal Full-text)

Although patients with peripheral vascular disease (PVD) show a high prevalence of coronary artery disease and myocardial hypertrophy, influences of PVD alone on cardiac hypertrophy, and its subcellular mechanism remain unclear. This study investigates the influences of PVD alone on cardiac muscles and the changes in biological parameters that potentially affect cardiac hypertrophy and cardioprotection. Several veins from rat hind limb were occluded. Two weeks later, the weight of heart relative to body weight in the occluded group increased by approximately 10% compared to that in the sham-operated group. A significant increase was observed in insulin-like growth factor-1 expression, and a significant decrease was observed in myostatin and mechano growth factor in the occluded group compared to the sham-operated group. Tissue concentration of nitric oxide, and content of heat shock protein (HSP)-72, HSP-90, and heat shock cognate protein-70 significantly decreased in the hypertrophied myocardium. These results suggest that peripheral occlusion alone causes cardiac hypertrophy associated with changes in biological parameters.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MSTNHumanperipheral vascular disease  ISOMstn (Rattus norvegicus) RGD 
MstnRatperipheral vascular disease  IEP  RGD 
MstnMouseperipheral vascular disease  ISOMstn (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mstn  (myostatin)

Genes (Mus musculus)
Mstn  (myostatin)

Genes (Homo sapiens)
MSTN  (myostatin)


Additional Information