RGD Reference Report - Effect of dimethylnitrosamine upon carbamoyl phosphate and ornithine utilization in rat liver. - Rat Genome Database

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Effect of dimethylnitrosamine upon carbamoyl phosphate and ornithine utilization in rat liver.

Authors: Karsai, T  Rady, P  Nagy, Z  Szondy, Z 
Citation: Karsai T, etal., Anticancer Res. 1985 Jul-Aug;5(4):441-4.
RGD ID: 2303531
Pubmed: PMID:2864015   (View Abstract at PubMed)

Newborn CFY rats were intraperitoneally treated with a single dose of dimethylnitrosamine. Changes in the activity of carbamoyl-phosphate synthase I and II, ornithine carbamoyltransferase, aspartate carbamoyltransferase and dihydroorotase, i.e. utilization of ornithine and carbamoyl-phosphate pools were followed for 300 days. One or two months after treatment the activity of enzymes which utilize ornithine and carbamoyl-phosphate was enhanced in the cytosol, whereas the activity of the intramitochondrial enzymes in urea synthesis was decreased. Changes in the utilization of ornithine and carbamoyl-phosphate pools, characteristic of proliferating tissues, appeared to be irreversible.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to amine  IEP 2303531; 2303531 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cad  (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase)
Cps1  (carbamoyl-phosphate synthase 1)


Additional Information