RGD Reference Report - Levodopa-mediated alteration in the activity of pyridoxal kinase in rat basal ganglia. - Rat Genome Database

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Levodopa-mediated alteration in the activity of pyridoxal kinase in rat basal ganglia.

Authors: Ebadi, M  Bifano, J  Klangkalya, B  Govitrapong, P  Durham, P 
Citation: Ebadi M, etal., Pharmacology. 1978;17(3):149-56.
RGD ID: 2303014
Pubmed: PMID:212768   (View Abstract at PubMed)

The acute intraperitoneal administration of 400 mg/kg of levodopa reduced the concentration of pyridoxal phosphate and increased the activity of pyridoxal kinase. The chronic oral administration of 100 mg/kg/day of levodopa did not alter the concentration of pyridoxal phosphate, but increased the activity of pyridoxal kinase in 7 days. This initial elevation in kinase activity returned to normal levels in 2 weeks, became reduced in 3 weeks and then fluctuated back to normal levels in 4 weeks. These results are interpreted to indicate that chronic intake of levodopa results in adaptive alteration in the activity of pyridoxal kinase. This maintains the steady-state concentration of pyridoxal phosphate in order to meet the levodopa-induced enhancement in decarboxylation reaction.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PdxkRatresponse to xenobiotic stimulus  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pdxk  (pyridoxal kinase)


Additional Information