RGD Reference Report - Ketamine enhances the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain. - Rat Genome Database

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Ketamine enhances the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain.

Authors: Takeyama, K  Yoshikawa, M  Oka, T  Kawaguchi, M  Suzuki, T  Hashimoto, A 
Citation: Takeyama K, etal., Eur J Pharmacol. 2006 Jul 1;540(1-3):82-6. Epub 2006 Apr 28.
RGD ID: 2302216
Pubmed: PMID:16716293   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ejphar.2006.04.021   (Journal Full-text)

We have evaluated the effects of the acute administration of noncompetitive N-methyl-D-aspartate receptor antagonist, ketamine, on the expression of serine racemase and D-amino acid oxidase mRNAs in several brain areas of rats. The ketamine administration produced a dose-dependent and transient elevation in the levels of serine racemase and D-amino acid oxidase mRNAs in all the brain areas. These findings suggest that there is a relationship between the gene expression of the d-serine-related enzymes and the blockade of the N-methyl-D-aspartate receptors.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to organic cyclic compound  IEP 2302216 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Srr  (serine racemase)


Additional Information