RGD Reference Report - The genetic control of rheumatoid factor production in a rat model of rheumatoid arthritis. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

The genetic control of rheumatoid factor production in a rat model of rheumatoid arthritis.

Authors: Wernhoff, P  Olofsson, P  Holmdahl, R 
Citation: Wernhoff P, etal., Arthritis Rheum. 2003 Dec;48(12):3584-96.
RGD ID: 2302026
Pubmed: PMID:14674011   (View Abstract at PubMed)
DOI: DOI:10.1002/art.11342   (Journal Full-text)

OBJECTIVE: To investigate the genetic regulation of rheumatoid factor (RF) in a rat model of rheumatoid arthritis, in order to gain understanding of the enigmatic role of RF in the disease. METHODS: IgM-RF and IgG-RF, as well as total levels of immunoglobulins of different subclasses, were measured in sera from rats with pristane-induced arthritis (PIA). The major gene regions were identified by linkage analysis of genetically segregating crosses. RESULTS: The production of RF was found to correlate with development of arthritis and to be higher in females than in males. Surprisingly, the relatively arthritis-resistant E3 strain had higher levels of RF than the arthritis-susceptible DA strain. In an (E3 x DA)F(2) cohort a major locus controlling the levels of IgM-RF in serum was identified on chromosome 11 (Rf1) and another on chromosome 16 (Rf3), and these were not related to arthritis susceptibility. However, the Rf2 locus on chromosome 4 controlled IgG-RF levels, IgG2a levels, and chronic arthritis in males (Pia5). Some previously defined arthritis loci (Pia4, Pia6, Pia7, and Pia8) were found to also control immunoglobulin levels in serum. CONCLUSION: RFs are produced in the rat PIA model and correlate with development of arthritis. Gene regions controlling RF and serum immunoglobulin levels were identified, of which some cosegregated with arthritis. This suggests a new focus of study to elucidate the role of RF in the pathogenesis of arthritis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DA/ZtmRhdRatrheumatoid arthritis susceptibilityIAGP pristane inducedRGD 
E3/ZtmRhdRatrheumatoid arthritis resistanceIAGPpristanecompared to DA/ZtmRhdRGD 
Pia27Ratrheumatoid arthritis no_associationIAGP pristane inducedRGD 
Pia28Ratrheumatoid arthritis  IAGP pristane inducedRGD 
Pia29Ratrheumatoid arthritis no_associationIAGP pristane inducedRGD 
Pia30Ratrheumatoid arthritis  IAGP pristane inducedRGD 
Pia31Ratrheumatoid arthritis  IAGP pristane inducedRGD 
Pia32Ratrheumatoid arthritis  IAGP pristane inducedRGD 
Pia33Ratrheumatoid arthritis  IAGP pristane inducedRGD 
Pia34Ratrheumatoid arthritis  IAGP pristane inducedRGD 
Pia35Ratrheumatoid arthritis  IAGP pristane inducedRGD 
Pia36Ratrheumatoid arthritis  IAGP pristane inducedRGD 
Pia37Ratrheumatoid arthritis  IAGP pristane inducedRGD 
Pia38Ratrheumatoid arthritis  IAGP pristane inducedRGD 
Pia39Ratrheumatoid arthritis  IAGP pristane inducedRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
E3/ZtmRhdRatdecreased susceptibility to induced arthritis inducedIAGPpristanecompared to DA/ZtmRhdRGD 
DA/ZtmRhdRatincreased susceptibility to induced arthritis inducedIAGPpristanecompared to E3/ZtmRhdRGD 
Pia27Ratincreased susceptibility to induced arthritis no_associationIDA pristane inducedRGD 
Pia28Ratincreased susceptibility to induced arthritis  IDA pristane inducedRGD 
Pia29Ratincreased susceptibility to induced arthritis no_associationIDA pristane inducedRGD 
Pia30Ratincreased susceptibility to induced arthritis  IDA pristane inducedRGD 
Pia31Ratincreased susceptibility to induced arthritis  IDA pristane inducedRGD 
Pia32Ratincreased susceptibility to induced arthritis  IDA pristane inducedRGD 
Pia33Ratincreased susceptibility to induced arthritis  IDA pristane inducedRGD 
Pia34Ratincreased susceptibility to induced arthritis  IDA pristane inducedRGD 
Pia35Ratincreased susceptibility to induced arthritis  IDA pristane inducedRGD 
Pia36Ratincreased susceptibility to induced arthritis  IDA pristane inducedRGD 
Pia37Ratincreased susceptibility to induced arthritis  IDA pristane inducedRGD 
Pia38Ratincreased susceptibility to induced arthritis severityIDA pristane inducedRGD 
Pia39Ratincreased susceptibility to induced arthritis  IDA pristane inducedRGD 
Pia27Ratjoint swelling no_associationIDA pristane inducedRGD 
Pia28Ratjoint swelling  IDA pristane inducedRGD 
Pia29Ratjoint swelling no_associationIDA pristane inducedRGD 
Pia30Ratjoint swelling  IDA pristane inducedRGD 
Pia31Ratjoint swelling  IDA pristane inducedRGD 
Pia32Ratjoint swelling  IDA pristane inducedRGD 
Pia33Ratjoint swelling  IDA pristane inducedRGD 
Pia34Ratjoint swelling  IDA pristane inducedRGD 
Pia35Ratjoint swelling  IDA pristane inducedRGD 
Pia36Ratjoint swelling  IDA pristane inducedRGD 
Pia37Ratjoint swelling  IDA pristane inducedRGD 
Pia38Ratjoint swelling  IDA pristane inducedRGD 
Pia39Ratjoint swelling  IDA pristane inducedRGD 
Objects Annotated

QTLs
Pia27  (Pristane induced arthritis QTL 27)
Pia28  (Pristane induced arthritis QTL 28)
Pia29  (Pristane induced arthritis QTL 29)
Pia30  (Pristane induced arthritis QTL 30)
Pia31  (Pristane induced arthritis QTL 31)
Pia32  (Pristane induced arthritis QTL 32)
Pia33  (Pristane induced arthritis QTL 33)
Pia34  (Pristane induced arthritis QTL 34)
Pia35  (Pristane induced arthritis QTL 35)
Pia36  (Pristane induced arthritis QTL 36)
Pia37  (Pristane induced arthritis QTL 37)
Pia38  (Pristane induced arthritis QTL 38)
Pia39  (Pristane induced arthritis QTL 39)

Strains
DA/ZtmRhd  (NA)
E3/ZtmRhd  (NA)

Objects referenced in this article
QTL Apr1 Acute phase response QTL 1 Rattus norvegicus
QTL Cia12 Collagen induced arthritis QTL 12 Rattus norvegicus
QTL Cia2 Collagen induced arthritis QTL 2 Rattus norvegicus
QTL Eae7 Experimental allergic encephalomyelitis QTL 7 Rattus norvegicus
QTL Eae8 Experimental allergic encephalomyelitis QTL 8 Rattus norvegicus
QTL Pia4 Pristane induced arthritis QTL 4 Rattus norvegicus
QTL Pia6 Pristane induced arthritis QTL 6 Rattus norvegicus
QTL Pia7 Pristane induced arthritis QTL 7 Rattus norvegicus
QTL Pia8 Pristane induced arthritis QTL 8 Rattus norvegicus

Additional Information