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Fine structural localization of glutamine synthetase in astrocytes of rat brain.

Authors: Norenberg, MD  Martinez-Hernandez, A 
Citation: Norenberg MD and Martinez-Hernandez A, Brain Res. 1979 Feb 2;161(2):303-10.
Pubmed: (View Article at PubMed) PMID:31966

The distribution of glutamine synthetase was determined in rat brain by ultrastructural immunocytochemistry. Except for trace amounts in a rare indeterminate glial cell, all the reaction product was located in astrocytes. Specifically, none was observed in neurons, synaptic endings, oligodendrocytes, microglial cells, pericytes, endothelial cells and other mesenchymal vascular elements. The results of this study clearly indicate that the astrocyte forms the compartment in brain concerned with glutamine synthesis, thereby assigning a key role to the astrocyte in the metabolism of ammonia and the putative neurotransmitters, glutamic acid and gamma-aminobutyric acid. The localization of glutamine synthetase in astrocytes additionally provides a valuable marker for a number of neurobiological studies.


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RGD Object Information
RGD ID: 2301552
Created: 2008-10-23
Species: All species
Last Modified: 2008-10-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.