RGD Reference Report - Cullin 5 gene expression in the rat cerebral cortex and hippocampus following traumatic brain injury (TBI). - Rat Genome Database

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Cullin 5 gene expression in the rat cerebral cortex and hippocampus following traumatic brain injury (TBI).

Authors: Yao, XL  Liu, J  Lee, E  Ling, GS  McCabe, JT 
Citation: Yao XL, etal., Neurosci Lett. 2006 Nov 27;409(1):65-9. Epub 2006 Sep 28.
RGD ID: 2301432
Pubmed: PMID:17010517   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neulet.2006.09.015   (Journal Full-text)

Cullin-5 (Cul-5), a member of the cullin gene family of scaffold proteins of E3 ubiquitin-ligase complexes, has a role in proteolysis and cell cycle regulation. We recently demonstrated that cul-5 mRNA is ubiquitously expressed in the central nervous system. The present study used quantitative real time polymerase chain reaction and western blotting to measure changes in cul-5 mRNA and Cul-5 protein expression, respectively, in the injured CNS in response to traumatic brain injury (TBI). cul-5 mRNA levels were significantly decreased in the ipsilateral rat cerebral cortex on Days 1 and 7, but not on Day 3 following TBI. In the ipsilateral hippocampus, cul-5 mRNA was significantly reduced on Day 1 after TBI. Cul-5 protein levels were significantly decreased in the ipsilateral rat cerebral cortex on Days 1-7 post-TBI while levels were significantly lower in the ipsilateral hippocampus on Days 3-7 post-TBI. Since Cul-5 is ubiquitously expressed in eukaryotic cells and is linked to proteasome-mediated protein degradation, it may have a role in CNS cell fate determination under conditions of traumatic stress.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Brain Injuries  ISOCul5 (Rattus norvegicus)2301432; 2301432mRNA more ...RGD 
Brain Injuries  IEP 2301432mRNA more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cul5  (cullin 5)

Genes (Mus musculus)
Cul5  (cullin 5)

Genes (Homo sapiens)
CUL5  (cullin 5)


Additional Information