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Quantitative histochemical studies of the hypothalamus enzymes of acetylcholine metabolism.

Authors: Packman, PM  Godfrey, DA  Williams, AD  Matschinsky, FM 
Citation: Packman PM, etal., J Histochem Cytochem. 1977 Nov;25(11):1237-46.
Pubmed: (View Article at PubMed) PMID:334962

The quantitative histochemical distribution of acetylcholinesterase and choline acetyltransferase activity has been measured in individual hypothalamic nuclei and median eminence, as well as in entire hypothalamic sections by a mapping technique. There was an 18-fold range of nuclear choline acetyltransferase activity with highest activities in the lateral preoptic nucleus and median eminence. There was a nine-fold range of nuclear acetylcholinesterase activity with highest activities in the lateral preoptic and magnocellular nuclei and lowest activity in the median eminence. The substantial gradients of choline acetyltransferase activity found in the hypothalamus indicate the importance of using a technique that provides an objective, permanent record of contiguous sample locations thereby allowing detailed analysis of tissue areas using, but not dependent on, anatomical boundaries.


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RGD Object Information
RGD ID: 2301197
Created: 2008-09-30
Species: All species
Last Modified: 2008-09-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.